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Penicillamine

Name: Penicillamine
Brand: Selleck Chemicals
SKU: S1853
Rating: 5 (1 reviews)

Cat.No.: S1853

Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.

Chemical Structure

Molecular Weight: 149.21

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Quality Control

Batch: S185301 Water]30 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 100.00%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

100.00

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Chemical Information, Storage & Stability

Molecular Weight	149.21	Formula	C₅H₁₁NO₂S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	52-67-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Dimethyl Cysteine			Smiles	CC(C)(C(C(=O)O)N)S

Solubility

In vitro
Batch:

Water : 30 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-05)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07465718	NOT_YET_RECRUITING	Wilson's Disease	Orphalan	2026-08	PHASE3
NCT06945081	RECRUITING	Wilson Disease; D-Penicillamine; Effect of D-penicilline on Cutaneous Elastity of Wilson's Patient	Centre Hospitalier Universitaire de Saint Etienne	2025-11-28
NCT03957720	UNKNOWN	Wilson's Disease	Second Affiliated Hospital, Zhejiang University, School of Medicine	2019-03-15	EARLY_PHASE1
NCT06103617	UNKNOWN	Head and Neck Cancer; Recurrent Cancer	Nanfang Hospital, Southern Medical University	2023-11-15	PHASE2
NCT03539952	COMPLETED	Wilson Disease	Orphalan	2018-09-03	PHASE3
NCT02426905	UNKNOWN	Wilson Disease	Univar BV	2016-01	PHASE4

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