Home Microbiology Antineoplastic and Immunosuppressive Antibiotics Inhibitor Neomycin sulfate

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Neomycin sulfate Antineoplastic and Immunosuppressive Antibiotics Inhibitor

Cat.No.: S2568

Neomycin sulfate (Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacterial infections.
Neomycin sulfate Antineoplastic and Immunosuppressive Antibiotics Inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 712.72

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Quality Control

Batch: Purity: >97.00%
97.00

Chemical Information, Storage & Stability

Molecular Weight 712.72 Formula

C23H46N6O13.H2SO4

 Storage (From the date of receipt)
CAS No. 28002-70-2 ,1405-10-3 Download SDF Storage of Stock Solutions

Synonyms Framycin sulfate Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro

Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV.

References
  • [4] https://pubmed.ncbi.nlm.nih.gov/11916853/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-24)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07549828 NOT_YET_RECRUITING
Acne; Atopic Dermatitis; Seborrheic Dermatitis; Psoriasis; Healthy Subjects (HS)
National Taiwan University Hospital
 2026-04-01
NCT06747611 RECRUITING
Alopecia Areata; Alopecia Totalis; Alopecia Universalis
University of Minnesota
 2025-08-21 PHASE2
NCT07180615 NOT_YET_RECRUITING
Surgical Site Infection; Colon Surgery; Surgical Site Infections
Universität Luzern
 2026-06-01 PHASE4
NCT04729322 ACTIVE_NOT_RECRUITING
Metastatic Colorectal Adenocarcinoma; Metastatic Small Intestinal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8; Stage IV Small Intestinal Adenocarcinoma AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
M.D. Anderson Cancer Center
 2021-02-22 PHASE2
NCT06148025 RECRUITING
Vaccine Response Impaired
South Australian Health and Medical Research Institute
 2023-11-23 PHASE4
NCT07490054 RECRUITING
Chronic Heart Failure
Melana Yuzefpolskaya, MD
 2025-09-01 PHASE1