AChR Agonists/Antagonist

Other Neuronal Signaling Inhibitors

Isoform-selective Products

• Featured Inhibitors
• Inhibitors (65)
• Modulators (13)
• Chemicals (6)
• Agonists (35)
• Activators (3)
• Antagonists (48)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S6887	Clozapine N-oxide (CNO chemical)	CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.	Molecular Medicine, November 23, 2025, nan Frontiers in Aging Neuroscience, November 11, 2022, 1040569 Cell Rep, 2026, 45(4):117246
S2462	Donepezil HCl	Donepezil HCl is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.This product is not soluble in PBS solution. Please do not dissolve it in PBS for administration.Solutions are unstable and should be fresh-prepared.	Anticancer Research, September 2018, 5149-5157 Anticancer Research, September 15, 2018, 5149-5157 Journal of the American Heart Association, May 12, 2014, e000804
S2497	Pancuronium dibromide	Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.	Biomedicines, November 28, 2022, 3056 eLife, March 22, 2019, e45399 Frontiers in Physiology, August 13, 2019, 1039
S2629	PNU-120596	PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.	PLoS One, August 9, 2013, e73581 British Journal of Pharmacology, August 2013, 1862-1878 Frontiers in Medicine, 2021, 642960
S2508	Scopolamine (LSM-4015) HBr	Scopolamine HBr (LSM-4015, NSC 61806, (-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.	Heliyon, 2024, 10(1):e23945 Heliyon, 2024, e23945 Zoological Research, 2023, 712-724
S4231	Pilocarpine HCl	Pilocarpine HCl (NSC 5746) is a selective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.	Viruses, 2024, 16(10)1559 Heliyon, 2024, 10(1):e23945 Theranostics, 2021, 11(12):5986-6005
S5073	Donepezil	Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.	Anticancer Research, September 2018, 5149-5157 Anticancer Research, September 15, 2018, 5149-5157 Journal of the American Heart Association, May 2014, e000804
S1805	Acetylcholine Chloride	The chemical compound Acetylcholine Chloride (ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.	Cell Mol Life Sci, 2024, 81(1):88 iScience, 2023, 26(3):106241 Cell, 2022, 185-21:3950-3965.e25
S1683	Ipratropium Bromide	Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).	bioRxiv, July 13, 2023, 2023.07.12.548707 Scientific Reports, February 19, 2026, 6980 bioRxiv, 2023, nan
S2614	Arecoline HBr	Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist.	BMC Molecular and Cell Biology, November 10, 2020, 80 Antioxidants (Basel), 2024, 13(4)430 Int J Oral Sci, 2024, 16(1):17
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