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Elesclomol (STA-4783)
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Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumour cells. Phase 3. Elesclomol specifically binds ferredoxin 1 (FDX1) ", "/" helices and ", " strand and inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol (STA-4783) is a potent copper ionophore and can be used in the research of copper-dependent cell death (cuproptosis).
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Nat Commun, 2025, 16(1):212
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Cell Prolif, 2025, e70101.
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Free Radic Biol Med, 2025, 237:65-75
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